I'd recommend you to use AVG, anyway, just running a single AV will not always get the wormstrojansviruses on your machine, head over to
http://housecall.trendmicro.com and do an online, free, full system scan and be sure and have the 'Auto Clean' checked. Also make sure youve visited Windows Update and applied all security patches. Regarding spywares etc. HijackThis is an excellent tool to discover and disable hijackers, but it requires expert skill, for more information regarding HJT point your browser to
http://www.aumha.org/a/hjttutor.htm and rtfm. Also make sure to update those programs before using. You can log your results generated by HJT and post'em anywhere on this forum and I'll be happy to guide you step by step.