Yes mate a noticble difference , I usually play 2160p High to Very High Setting without AA on very demanding titles such as Mass Effect Andromeda the min fps is 45 fps reaching 60fps , when I OC'd the 1080ti Strix Gaming OC the Min Fps pushed to 53 fps with enabling AA too (FXAA) , on average you will gainn 8 fps without sacificing on the image quality - High to Very High Settings (Including Shadows and HBAO +). Very playable experience on native 4k with very good image quality.
Strix coolig is great , A top notch 1080ti performer.